Researcher
Eric Kandel
Profile
- Institution
- Columbia University
- Field
- Neuroscience
Eric Kandel is an Austrian-American neuroscientist and psychiatrist at Columbia University who received the 2000 Nobel Prize in Physiology or Medicine for his discoveries of how the brain stores memories at the molecular and cellular level. Using the marine snail Aplysia californica as a model organism, Kandel demonstrated that learning and memory involve changes in the strength of synaptic connections (synaptic plasticity) and identified the molecular mechanisms underlying short-term and long-term memory formation, including the role of cAMP, protein kinase A, CREB transcription factors, and new protein synthesis. His research provided the first molecular explanation for memory consolidation and showed that the same mechanisms underlie memory across species from invertebrates to mammals. Kandel also contributed pioneering work connecting psychoanalysis to neuroscience and advocating for the neuroscience of mental illness. His elucidation of memory mechanisms has guided drug development for memory disorders, including Alzheimer's disease, PTSD, and schizophrenia. Pharmaceutical companies developing cognitive enhancers and CREB-pathway modulators draw directly on his foundational research.
Industry Ties
- Industry Ties
- Axovant SciencesBiohaven PharmaceuticalsRocheEli Lilly