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PhD Candidates

Noura Benali

Noura Benali is a PhD candidate in Medicinal Chemistry at Mohammed V University in Rabat, supervised by Prof. Khalid Laatiris. Her thesis designs, synthesises and evaluates fluoroquinolone-carbazole hybrid scaffolds as inhibitors of mycobacterial DNA gyrase, demonstrating bactericidal activity against rifampicin and isoniazid-resistant Mycobacterium tuberculosis clinical isolates from Moroccan sanatoriums. Eight publications in European Journal of Medicinal Chemistry and Bioorganic and Medicinal Chemistry Letters document her synthesis and biological evaluation work. Noura received a Moroccan Ministry of Higher Education Excellency grant and participated in a TB drug discovery programme with the Institute of Organic Chemistry and Biochemistry in Prague. She is being actively recruited by a European TB drug discovery consortium based in Basel. Her lead compound shows MIC values below 0.06 micrograms per mL against extensively drug-resistant TB strains.

Details

Advisor
Prof. Khalid Laatiris
Field
Medicinal Chemistry
Institution
Mohammed V University
Skills
medicinal chemistry synthesisNMRHPLCantimicrobial assaysmolecular dockingMIC determinationdrug discovery
Thesis
Fluoroquinolone-carbazole hybrids as antitubercular agents against drug-resistant Mycobacterium tuberculosis
Transition Signals
Moroccan Ministry of Higher Education Excellency grantPrague IOCB TB drug discovery programme participationBasel TB drug discovery consortium recruitment in progress
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