RESEARCH FIELD

Organoid Biology

Organoid biology creates three-dimensional, self-organizing miniaturized organ-like structures from stem cells that recapitulate the architecture and function of human organs in culture. Intestinal organoids preserve patient-specific epithelial genetics for personalized drug response testing and cystic fibrosis mutation correction studies. Cerebral organoids model early human brain development and neurodevelopmental disorders inaccessible to animal models. Tumor-derived organoids capture the heterogeneity of patient biopsies and predict chemotherapy response in clinical trials. Advances in vascularization and immune cell co-culture are addressing a key limitation: the absence of blood supply and systemic interactions in classical organoid systems. Organoids are reshaping drug development, disease modeling, and regenerative medicine.