Integra LifeSciences

Integra LifeSciences is a Princeton, New Jersey-based medical technology company founded in 1989 that develops and manufactures regenerative tissue technologies, neurosurgery tools, and reconstructive surgery devices with particular strength in neurocritical care monitoring and spinal and peripheral nerve surgery. In the neuroscience research community, Integra is best known as the manufacturer of the Camino ICP monitor, which uses a miniature fiber optic strain gauge transducer for continuous intracranial pressure monitoring through a bolt placed in the skull, widely used in traumatic brain injury research and clinical management. Their brain tissue oxygenation (Licox) monitors provide continuous real-time measurement of brain parenchymal oxygen tension, enabling research into secondary brain injury mechanisms and cerebral autoregulation. Integra's Codman programmable shunt valves for hydrocephalus management, and their Certas Plus valve systems, are subjects of comparative effectiveness research in pediatric and adult neurosurgery. The company's Duragen and Durepair dural regeneration matrices, based on collagen scaffolds derived from bovine dermis, are studied as models for dural repair and neural interface implantation research. Their Selectstar robotic stereotaxy system provides frameless navigation for electrode and probe placement research. Through their acquisition of Salto Talaris and DuraSeal, Integra also serves orthopedic and spinal cord injury research communities. Their acquisition of Titan Spine and the custom titanium implant fabrication capabilities extend their research presence to bone regeneration and spinal fusion biomechanics.