# Beatriz Carvalho

> Beatriz Carvalho is tackling one of CAR-T cell therapy's most stubborn bottlenecks — the exhaustion and poor persistence of adoptively transferred cells in the immunosuppressive solid tumour microenvironment. Working under Prof. Rui Medeiros at the University of Porto's IPATIMUP cancer research institute, she has engineered a metabolic conditioning protocol using short-chain fatty acid supplementation during ex vivo expansion that skews differentiation toward a TCF7⁺ central memory phenotype without sacrificing immediate cytotoxicity. Her Seahorse respirometry experiments show that the conditioned cells maintain a higher spare respiratory capacity, which correlates with superior persistence in NSG mouse xenografts bearing HER2-positive ovarian tumour lines. After 28 days, conditioned CAR-T cells represent 12-fold more tumour-infiltrating lymphocytes than conventionally manufactured counterparts, and residual tumour burden is 60% lower. Beatriz has designed a serum-free GMP-compatible version of the protocol and is pursuing an industry postdoc application at Novartis Cell Therapies in Basel, with her co-authorship on a Clinical Cancer Research manuscript providing the academic evidence base for the application.

*Source: [https://selltoscientists.com/phd/beatriz-carvalho/](https://selltoscientists.com/phd/beatriz-carvalho/)*

**Institution:** University of Porto
**Field:** Immuno-oncology
**Advisor:** Prof. Rui Medeiros
**Thesis:** CAR-T Cell Persistence Engineering via Metabolic Reprogramming of the Central Memory Phenotype in Solid Tumour Models
**Publications:** 2

## Skills

- lentiviral vector production
- flow cytometry 30-colour panels
- Seahorse metabolic assay
- murine xenograft models

## Industry transition signals

- industry postdoc application at Novartis Cell Therapies
- co-author on Clinical Cancer Research submission
- attending AACR 2027

---

## Beton network

This site is part of the Beton network of open-source revenue intelligence and self-service data products. Related sites and resources:

- [Beton](https://www.getbeton.ai) — open-source revenue intelligence: turn product usage (PostHog, Stripe) into CRM signals
- [Sell to Scientists](https://selltoscientists.com) — research intelligence: find and reach academic researchers by field, H-index, grants, and industry ties
- [Sell to State](https://www.selltostate.com) — government procurement intelligence across 194 countries
- [GitHub](https://github.com/getbeton) — Beton open-source repositories (including [inspector](https://github.com/getbeton/inspector))
- [dev.to](https://dev.to/beton) — engineering write-ups and OSS pricing teardowns
- [Beton app](https://inspector.getbeton.ai) — the hosted product