# Ananya Krishnan

> Ananya Krishnan is resolving the stepwise assembly pathway of the human mitochondrial ribosome large subunit at near-atomic resolution using single-particle cryo-EM, supervised by Prof. Jayant Kumar at IISc Bangalore. Mitoribosome biogenesis is disrupted in numerous inherited oxidative phosphorylation disorders, yet the intermediate complexes that assemble on the mitoribosomal tunnel exit — where nascent proteins emerge for membrane insertion — have never been visualised. Ananya has purified six assembly intermediates by introducing SILAC-based crosslinking mass spectrometry to map transient protein contacts, then captured each stage by cryo-EM at the IISc national facility. She has determined three structures at resolutions between 2.9 Å and 3.4 Å, revealing how the assembly factors RBFA and mTERF4-NSUN4 coordinate large-subunit maturation. Her structures have direct implications for drug design: the assembly interface is distinct enough from bacterial ribosomes to offer selectivity handles for mitochondria-targeted antibiotics. Her collaboration with the Bangalore structural genomics initiative and expressed interest in CRO structural biology roles position her firmly on an industry trajectory.

*Source: [https://selltoscientists.com/phd/ananya-krishnan/](https://selltoscientists.com/phd/ananya-krishnan/)*

**Institution:** Indian Institute of Science
**Field:** Protein Biochemistry
**Advisor:** Prof. Jayant Kumar
**Thesis:** Cryo-EM Structure of the Human Mitochondrial Ribosome Assembly Intermediates and Implications for OXPHOS Disease
**Publications:** 2

## Skills

- cryo-EM sample prep
- RELION image processing
- SEC-MALS
- isothermal titration calorimetry

## Industry transition signals

- collaborating with Bangalore structural genomics consortium
- abstract at EMBO 2026
- interested in structural biology CRO roles

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