# Chemical Biology

> Chemical biology uses small molecules as both research tools and therapeutic leads, applying the precision of chemistry to probe and manipulate biological processes at the molecular level. Activity-based protein profiling maps the activity landscape of entire enzyme families across cellular proteomes, identifying new drug targets and resistance mechanisms. Bioorthogonal chemistry enables labeling of biomolecules inside living organisms without disrupting natural processes. PROTAC technology hijacks the cellular degradation machinery to destroy disease-causing proteins, representing a paradigm shift in pharmacology. Chemical biology has become essential for translating genomic insights into actionable drug discovery programs.

*Source: [https://selltoscientists.com/fields/chemical-biology/](https://selltoscientists.com/fields/chemical-biology/)*

**Researcher count:** 22,000
**Average funding:** $530K

## Subfields

- Chemical Genetics
- Activity-Based Proteomics
- Chemical Epigenetics
- Bioorthogonal Chemistry
- Natural Product Chemistry

## Key technologies

- Activity-Based Probes
- Photo-Crosslinking
- Chemoproteomics
- PROTAC Technology
- DNA-Encoded Chemical Libraries

## Top institutions

- Broad Institute
- Scripps Research Institute
- Harvard University
- University of Cambridge
- ETH Zürich

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