# Nikon Instruments

> Nikon Instruments is the scientific microscopy division of Nikon Corporation, headquartered in Tokyo, Japan, that manufactures optical microscopes, imaging systems, and analysis software for biological and materials science research. Nikon's Ti2-E and Ti2-U inverted research microscopes are the current flagship platforms for live-cell imaging, widely adopted in cell biology, developmental biology, and drug discovery labs for their Perfect Focus System (PFS) hardware autofocus that maintains focal plane stability over hours-long time-lapse experiments without user intervention. The Ti2-LAPP (Laser Autofocus Point Positioning) system enables rapid, tile-based automated imaging across multiwell plates in high-content screening workflows. Nikon's A1R HD25+ confocal laser scanning microscope achieves very high scanning speeds through resonant galvano scanning mirrors combined with spectral detector arrays, enabling fast acquisition of multi-channel 3D fluorescence images in dynamic biological systems. Their N-STORM super-resolution microscope based on STORM (stochastic optical reconstruction microscopy) achieves approximately 20 nm lateral resolution, enabling visualization of molecular-scale structures such as clathrin lattices, actin networks, and nuclear pore complexes. Nikon's NiS-Elements imaging software is an integrated acquisition and analysis platform supporting automated experiment design, deconvolution, cell tracking, and morphological analysis. Their Eclipse LV upright metallurgical microscopes and confocal wafer inspection systems address research in materials science and semiconductor process development. Nikon's stereomicroscopes and SMZ series remain standard tools in developmental biology and neuroscience dissection labs.

*Source: [https://selltoscientists.com/companies/nikon-instruments/](https://selltoscientists.com/companies/nikon-instruments/)*

**Industry:** Scientific Microscopy
**R&D spend:** $380M
**Academic collaborations:** 1150
**Patents:** 5,300

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